IgG1/IgE ratio is relevant for the protective effect of an alum-adjuvated allergen vaccine in a murine model of local allergen challenge
نویسندگان
چکیده
Background The new anti allergic vaccine is based on purified allergens from Dermatophagoides siboney and the combination adjuvant containing a TLR-4 ligand and alum. We propose that IgG1/IgE ratio is effective to assess the clinical efficacy of this experimental vaccine. Aim: To evaluate the immunogenicity of formulation variants of a D. siboney adjuvanted vaccine with varying levels of allergen adsorption on to alum.
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